Barzan Wormhole
The Barzan wormhole, located near Barzan II, was discovered in 2366. At the time, it was believed to be the first and only stable wormhole to ever exist, connecting the Alpha Quadrant with the Gamma Quadrant.
The wormhole appeared precisely every 233 minutes, which, according to the Barzan scientists, is due to radiation build up in the accretion disk; its visible burst was very brief. A Barzan probe sent through the wormhole discovered that its terminus was located beyond the Denkiri Arm in the Gamma Quadrant. During a later investigation, it was discovered that the terminus also appeared at a location in Sector 3556 of the Delta Quadrant, nearly 200 light years from the intitial report.
The discovery of the wormhole provided the Barzans with their first true natural resource. Consequently, they decided to capitalize on the opportunity and negotiations to secure rights to the wormhole took place on board the USS Enterprise-D between representatives of the Caldonians, Chrysalians, the Federation, and Ferengi. However these ended when a pair of Ferengi were trapped on the far side of the wormhole. It turned out that the non-Barzan terminus of the wormhole was unstable so it could not be used as a safe transport system. (TNG: "The Price")
These Ferengi were discovered in 2373 posing as gods on the planet of the Takarians in the Delta Quadrant by the USS Voyager. During their escape, the pair disrupted the wormhole's subspace axis and made both ends unstable. It is not known where (or if) they emerged. (VOY: "False Profits")